The data analysis showed new-onset T2D was associated with a 48 per cent increased risk of obesity related cancers in men and a 24 per cent increased risk in women
Image for representational purposes only (Photo Courtesy: iStock)
A new diagnosis of type 2 diabetes (T2D) has been linked to a subsequent increase in the risk of developing some, but not all, obesity related cancers, according to new research.
ADVERTISEMENT
Previous research has described associations between type 2 diabetes mellitus and higher risk of several obesity-related cancers.
However, it remains unclear whether these associations are causal, due to confounding (their mutual risk factor of obesity); immortal time bias (many studies combine prevalent and new-onset T2D); or time detection bias (for example, the co-diagnosis of two relatively common conditions at the same time).
In this study, to be presented at European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May), the authors aimed to address these previous methodological flaws.
They performed a matched cohort control study within UK Biobank of new-onset T2D (defined by date of first reported non-insulin dependent diabetes) versus unexposed individuals matched (1 participant to 3 controls) on body mass index (BMI), age, and sex.
A total of 23,750 participants with T2D were matched with 71,123 controls. Over a median follow-up time of 5 years, there were 2431 new primary cancers among T2D participants and 5184 new primary cancers among matched controls.
The data analysis showed new-onset T2D was associated with a 48 per cent increased risk of obesity related cancers in men and a 24 per cent increased risk in women – an effect independent of BMI. However, there were no associations with several site-specific ORCs – notably, endometrial, and post-menopausal breast cancer in women
There were positive associations found – new onset T2D increased the risk for bowel cancer by 27 per cent in men and 34 per cent in women; for pancreatic cancer by 74 per cent in men and a near-doubling of risk in women. For liver cancer new onset T2D was associated with a near-quadrupling of risk in men and near 5-fold increased risk in women.
“At this stage, we are unsure whether these differences in men and women are due to a sex-dependent biological pathway such as hormone levels, insulin sensitivity, body fat composition, or due to a simple difference in the number of cancers found in men and women within UK Biobank by chance,” said the study authors.
This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
Subscribe today by clicking the link and stay updated with the latest news!" Click here!
